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Friday 26 September 2014

Liposomal Encapsulation Delivers Medications More Efficiently

By Jody Leach


Drugs used to fight disease typically target specific physical systems or organs. Intravenous drips and injections are the most directly effective delivery method, transferring those medications directly to the blood. Orally administered drugs face degradation from the substances that accompany normal digestion. Liposomal encapsulation creates a protective bubble that wards off acids, while encouraging absorption.

Scientists first became aware of the process during the 1960s, and their discovery ultimately led to new and more effective means of administering drugs internally. Today, it is widely used in the treatment of age-related degenerative conditions affecting vision, stubborn fungal infections, and even some kinds of cancer. Although standard methods of delivery still predominate medically, encapsulation has proven to be a viable alternative.

In order to allow drugs to pass through the digestive tract without being broken down, they must be safely encased within a non-toxic protective barrier. Effectively shielding these individual microscopic capsules is possible when using an organic agent that mimics normal cellular walls. When that substance is activated using a variety of current methods, small individual bubbles made of liposomes are formed.

They are microscopic, and permit the medication protected inside to safely reach the bloodstream via the small intestine, where they are directly absorbed. This not only improves the overall therapeutic intent in many cases, but can also reduce the possibility of harmful side effects. Not all medications are suitable for this method of delivery, which is most effective with water-soluble drugs.

Because the process is not invasive and generates fewer negative reactions, there are immediately and obvious advantages. Liposomes are completely biodegradable, and contain no petroleum-derived compounds or other unwanted toxic substances. They easily survive an onslaught of powerful acid, and later function as mini time-release stations within the small intestine. Powerful cancer drugs administered in this way create less collateral damage to surrounding tissues.

While immediately useful in delivering medication, the process does have drawbacks. The cost of production remains high, but will very likely decrease as research into new product uses expands. There have been issues regarding seal leakage, and common oxidation may also reduce effectiveness. The half-lives of certain drugs decrease using this process, and long-term stability may be shortened. Even so, the potential benefits outweigh known negatives.

The past decade has seen a transition from strictly medical venue to include delivery of nutritional supplements and cosmetic materials. Anecdotal evidence of an increase in physical well-being associated with administering vitamins and minerals in this way are common. Vitamin C has long been touted as a natural way to combat the effects of upper respiratory infections, and this method is said to provide noticeably better results than pills alone.

Although information highlighting consumer ability to create encapsulated vitamins, minerals, and even herbal extracts is readily available, making high-quality formulations can be costly and involved, and will not effectively combat the normal issues associated with aging. As support and development of this process continues in the medical world, the public will benefit most from it being used in conjunction with health regimens that have already been proven effective.




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Joining The Right Etobicoke Volleyball League

By Kerri Stout


Participating in various forms of free time is usually a source of fun and excitement for people. There are many instances where people are interested in making sure their activities are successfully managed in regard to connecting with others and being able to appreciate local enthusiasm in the process. Anyone considering this sport should be versed in deciding on the right Etobicoke volleyball league to make sure their needs are successfully met.

Volleyball leagues are designed to help people successfully participate in this sporting event in a fun and community based manner. People are often focused on the amateur leagues that are found throughout their city when lacking the resources for individual playing and are considering their abilities to make new friends. The joining decisions that people make are usually quite difficult and personal when completed.

Consumers in Etobicoke that are focused on this sporting event and opportunity have a multitude of options to consider. Attempting to find a league that is fun and based on the preferences of the potential player is quite challenging when considering all their similarities. The right decision is made when several ideas are carefully focused on.

Referrals from friends and relatives are often among the most helpful sources of insight for anyone in need. The referrals that are offered from people are usually based on their direct participation or the actual knowledge that others have about various programs throughout the city. People using this information often feel more confident and efficient when narrowing down their options while even having someone that is already known in many instances to join with.

The requirements for joining and participating in any particular league can also be essential to weigh in. A majority of leagues make it necessary for people to be of a specific gender or age and require that various skill levels are attained as well. Requirements are clearly spelled out in most cases and should be examined in order to avoid difficulties with the actual joining process.

Paying close attention to convenience is also an integral step in making the right decision. People are now commonly required to manage difficult and stressful schedules which creates a unique challenge when trying to participate in leagues that might be inconvenient to access and scheduled at times that are not able to be committed to for any particular reason. Convenient practice and game locations along with flexible time frames are the most productive leagues for anyone to consider.

The various games and tournaments that are hosted by the league can be quite useful as well. Participating in fun games and events for any team is a great way to build skill and interaction with other members while creating a common goal and excitement along the way. The most extensive listing of activities is the most helpful for people to consider that are looking forward to active participation.

Any fees that might be associated with a particular league can also be essential for interested participants. Many leagues require that members pay for uniforms and various fees associated with games and tournaments. The lowest fee structures associated with full membership are often the most useful for anyone to consider while trying to manage their budget and still enjoy their favorite activities.




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